MAGAININ 2
CAS 108433-95-0 MFCD00133522
化学结构图
SMILES: CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(O)=O
化学属性
| Mol. Formula | C114H180N30O29S |
|---|---|
| Mol. Weight | 2466.90 |
别名和识别编码
| Chemical Name | Magainin II |
|---|---|
| MDL Number | MFCD00133522 |
| CAS Number | 108433-95-0 |
| Synonym | |
| PubChem Substance ID | 329817906 |
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分类
- {SA} Antibacterial, Antibiotic Peptides, Antibiotics, Antifungal,
- Antibacterial, Antibiotic Peptides, Antibiotics, Antifungal, Antiviral, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators, Immunomodulators and Antibiotics, Interferes with Cell Membrane Permeability (Ionophores), L - Z, M, Mechanism of Action, Peptides, Peptides and Proteins, Peptides for Cell Biology, Spectrum of Activity
- {SNA} Antibacterial,
相关文献及参考
- Zasloff, M. Proc. Natl. Acad. Sci. U. S. A. 84 , 5449, (1987) 摘要
- Cannon, M. Nature 328 , 478, (1987) 摘要
- Giacometti, A., et al., In-vitro activity of cationic peptides alone and in combination with clinically used antimicrobial agents against Pseudomonas aeruginosa. J. Antimicrob. Chemother. 44 , 641-645, (1999) 摘要
- Huang, H., Action of antimicrobial peptides: Two-state model. Biochemistry 39 , 8347, (2000) 摘要
- Wieprecht, T., Binding of antibacterial magainin peptides to electrically neutral membranes: thermodynamics and structure. Biochemistry 38 , 10377, (1999) 摘要
- Giacometti A., et al., In vitro activities of polycationic peptides alone and in combination with clinically used antimicrobial agents against Rhodococcus equi. Antimicrob. Agents Chemother. 43 , 2093-2096, (1999) 摘要
- Helmerhorst, E.J., A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides. FEBS Lett. 449 , 105, (1999) 摘要
- Matsuzaki K., Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim. Biophys. Acta 1376 , 391-400, (1998) 摘要
