Exemestane 甾体芳香化酶(CYP19)抑制剂
CAS 107868-30-4 MFCD00866994
化学结构图
SMILES: C[C@@]12CC[C@@H]3[C@H](CC(=C)C4=CC(=O)C=C[C@]43C)[C@H]1CCC2=O |&1:1,4,5,15,17|
化学属性
| Mol. Formula | C20H24O2 |
|---|---|
| Mol. Weight | 296.40 |
别名和识别编码
| Chemical Name | Exemestane |
|---|---|
| CAS Number | 107868-30-4 |
| Synonym | 6-Methyleneandrosta-1,4-diene-3,17-dione FCE-24304 Aromasin |
| MDL Number | MFCD00866994 |
| Chemical Name Translation | 甾体芳香化酶(CYP19)抑制剂 |
| LabNetwork Molecule ID | LN00194655 |
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分类
- Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, Pfizer Compounds, Steroid Hormones
- {SA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, Pfizer Compounds, Steroid Hormones
产品应用
- An antineoplastic (hormonal).
相关文献及参考
- Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988),
- Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992),
- Koutras, A., et al, Antiproliferative effect of exemestane in lung cancer cells. Mol. Cancer Res. 8 , 109, (2009) 摘要
- Miller, W.R., et al., Aromatase inhibitors: are there differnces between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 , 829-837, (2008)
- Soudon, J., Comparison of in vitro exemestane activity versus other antiaromatase agents. Clin. Biochem. 1 , S68-73, (2000) 摘要
- Merck 14 ,3913
安全信息
GHS Symbol
- P305+P351+P338
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H319 Causes serious eye irritation 严重刺激眼睛
