6-[3-(1-三环[3.3.1.13.7]癸烷)-4-甲氧基-苯基]萘-2-甲酸 6-[3-(1-金刚烷基)-4-甲氧苯基]-2-萘甲酸
CAS 106685-40-9 MFCD03106112
化学结构图
SMILES: COC1=CC=C(C=C1[C@@]12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C1=CC2=CC=C(C=C2C=C1)C(O)=O |&1:8,10,12,15|
化学属性
| Mol. Formula | C28H28O3 |
|---|---|
| Mol. Weight | 412.53 |
别名和识别编码
| Chemical Name | 6-[3-(1-三环[3.3.1.13.7]癸烷)-4-甲氧基-苯基]萘-2-甲酸 |
|---|---|
| CAS Number | 106685-40-9 |
| Alfabeta Name | ADAMANTANYLMETHOXYPHENYLNAPHTHOICACID 63142(())-------- |
| MDL Number | MFCD03106112 |
| Synonym | Adapalene 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid CD-271 Differin 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid |
| Chemical Name Translation | 6-[3-(1-金刚烷基)-4-甲氧苯基]-2-萘甲酸 |
| Reaxys-RN | 7393980 |
| Merck Number | 150 |
| PubChem Substance ID | 172088913 |
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分类
- Pharmaceuticals
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
- Aromatics
- Intermediates & Fine Chemicals,
产品应用
- Retinoid selective for retinoic acid receptor (RAR) subtypes ? and ?. Antiacne.
相关文献及参考
- [2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.
- [3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.
- Bernard, B.A., et al.: Skin Pharmacol., 6, 61 (1993),
- Griffiths, C.E.M., et al.: J. Invest. Dermatol., 101, 325 (1993),
- Waugh, J., et al.: Drugs, 64, 1465 (2004),
- [1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.
- [1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.
- [2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.
- [3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in
安全信息
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
