CAS 106-88-7 MFCD00005153-1,2-Epoxybutane 1,2-环氧丁烷 TAO{mole}

1,2-Epoxybutane 1,2-环氧丁烷

CAS 106-88-7 MFCD00005153

化学结构图

SMILES: CCC1CO1

化学属性

Mol. Formula	C4H8O
Mol. Weight	72.11
Refractive index	1.3830 to 1.3850
Boiling Point	63
Density	0.829
Autoignition Point	698 °F
Vapor Density	2.2 (vs air)
Vapor Pressure	140 mmHg ( 20 °C)
Flash Point	-22°C
Solubility	溶于水，可混溶于多数有机溶剂。

别名和识别编码

Chemical Name	1,2-Epoxybutane
Synonym	{uni_hamburg} 1,2-Butylenoxid 1-Butylene oxide Ethyloxirane Ethyloxirane <undefined optical isomer> 2-Ethyloxirane ethyl-oxirane 1,2-epoxybutylene butane, 1,2-epoxy- 1,2-Monoepoxybutane ETHYLOXIRANE 1,2-EPOXYBUTANE 氧化丁烯 ethyloxirane 1,2-環氧丁烷 1,2-butene oxide 乙基环氧乙烷 1-丁烯氧化物乙基环氧乙烷氧化丁烯环氧丁烷 1,2-Butene oxide 1,2-epoxy-butan 2-ethyloxirane But-1-ene oxide (R,S)-2-Ethyl-oxirane a-butylene oxide (±)-Ethyloxirane (±)-2-Ethyloxirane (R/S)-1,2-Epoxybutane 1,2-环氧丁烷 1,2-epoxybutane(1,2-butyleneoxide) NCI-C55527 (±)-1,2-epoxy-butane 1,2-Butylene oxide Ethylene oxide, ethyl- 1-butene oxide ethylethylene oxide
Beilstein Registry Number	17(2)17
CAS Number	106-88-7
PubChem Substance ID	87563720
EC Number	203-438-2
MDL Number	MFCD00005153
Reaxys-RN	102411
Chemical Name Translation	1,2-环氧丁烷
Wiswesser Line Notation	T3OTJ B2
LabNetwork Molecule ID	LN00220859
InChI	InChI=1S/C4H8O/c1-2-4-3-5-4/h4H,2-3H2,1H3

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安全信息

GHS Symbol

WGK Germany2

Hazard Codes 3

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H351 Suspected of causing cancer 怀疑致癌
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H302+H312+H332
H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

RTECSEK3675000

Precautionary statements

P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P308+P313
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P337+P313
P403+P233
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P303+P361+P353
P201 Obtain special instructions before use. 使用前获取专门指示。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P370+P378
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P304+P340+P312
P305 IF IN EYES: 如果进入眼睛

Signal word

UN Number 3022

Safety Statements

S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S29 Do not empty into drains 不要排入下水道；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R52/53
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R11 Highly flammable 非常易燃

Packing GroupII

Hazard Class3

Warnings 危化品目录(2015)

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 ppm/6H/5D/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-329,1988

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 398 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-329,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-168510

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2100 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 6000 ppm
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,901,1979

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5 pph
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher informatio

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   46,277,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep.

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 249,55,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 16OO umol/L
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   3,75,1983

TYPE OF TEST

{ha

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1000 ppm/7H
SEX/DURATION            : female 1-24 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB81-168510

Restrict 危险品

其他信息

图谱信息:1,2-环氧丁烷(106-88-7)核磁图( 1 HNMR) 1,2-环氧丁烷(106-88-7)Raman光谱 1,2-环氧丁烷(106-88-7)质谱(MS) 1,2-环氧丁烷(106-88-7)核磁图( 13 CNMR) 1,2-环氧丁烷(106-88-7)红外图谱(IR1) 1,2-环氧丁烷(106-88-7)红外图谱(IR2)
上游原料:次氯酸
蒸气密度:2.2 (vs air)
MSDS 信息:1,2-环氧丁烷(106-88-7).msds
类别:易燃液体
储运特性:库房通风低温干燥; 与氧化剂,食品原料分开存放; 不宜久储, 以防爆炸
下游产品:1,2-丁二醇
用途一:用于制造中间体和聚合物，例如用来生产1,2-丁二醇。还用来代替丙酮作为硝基漆的稀释剂，1,2-环氧丁烷也可作为色谱分析的标准物质。
外观性质:无色液体，有醚样的气味。
TCI Shanghai:1,2-环氧丁烷 1,2-Butylene Oxide,>;99.0%(GC)(106-88-7)
急性毒性:口服- 大鼠 LD50: 500 毫克/ 公斤
可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生刺激烟雾
方法一:工业上，环氧丁烷来源于环氧丙烷生产的副产品回收，在用裂解尾气经次氯酸化生产环氧乙烷、环氧丙烷过程中，可得环氧丙烷塔釜残液。其中含环氧丁烷74.6%，环氧丙烷16.7%，环氧乙烷0.7%，水3.1%，还有少量高沸物。通过蒸馏，从塔丁收集50-70℃的馏分，冷凝后除去水分，获得含量约87%的1,2-环氧丁烷成品，如需要更高纯度，则可进一步分馏。
1,2-环氧丁烷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 TB071901 1,2-环氧丁烷;1,2-氧化丁烯 500ml 468元 2011/04/16 B0719 1,2-环氧丁烷 1,2-Butylene Oxide 500ML 437元 2011/04/16 B0719 1,2-环氧丁烷 1,2-Butylene Oxide 25ML 167元
灭火剂:干粉、二氧化碳、泡沫、1211灭火剂
职业标准:TWA 200 PPM
刺激数据:皮肤- 兔子 500 毫克/ 24小时轻度; 眼睛- 兔子 100 毫克/ 24小时中度
毒性分级:高毒
MOL 文件:106-88-7.mol
Sigma Aldrich:106-88-7(sigmaaldrich)
爆炸物危险特性:与空气混合可爆; 在空气中久放生成可爆过氧化物
蒸气压:140 mm Hg ( 20 °C)