SU5614 (Z)-5-氯-3-((3,5-二甲基-1H-吡咯-2-基)亚甲基)吲哚啉-2-酮
CAS 1055412-47-9 MFCD155412479
化学结构图
SMILES: Cc1cc(C)c(/C=C2\C(=O)Nc3ccc(Cl)cc32)[nH]1
化学属性
| Mol. Weight | 272.73 |
|---|---|
| Mol. Formula | C15H13ClN2O |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 1055412-47-9 |
|---|---|
| Chemical Name | SU5614 |
| Synonym | (3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one SU5614; SU 5614; SU5614. |
| MDL Number | MFCD08443928 |
| PubChem Substance ID | 329823735 |
| Chemical Name Translation | (Z)-5-氯-3-((3,5-二甲基-1H-吡咯-2-基)亚甲基)吲哚啉-2-酮 |
| Formula | C15H13ClN2O |
| IUPAC Name | (3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| InChIKey | XLBQNZICMYZIQT-GHXNOFRVSA-N |
| InChI | InChI=1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7- |
| Canonical SMILES | O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3 |
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分类
- Inhibitors
- Heterocycles
- Pharmaceuticals
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, S, Tyrosine Kinase (TK), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Pfizer compou
产品应用
- SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.
相关文献及参考
- Sun, L., et al.: J. Med. Chem., 41, 2588 (1998),
- Knowles, P., et al.: J. Biol. Chem., 23, 23 (2006),
- Rizzi, E., et al.: Bioorg. Med. Chem. Lett., 17, 3962 (2007),
安全信息
- R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
