Tyrphostin A9 2-(3,5-二叔丁基-4-羟基苯亚甲基)丙二腈
CAS 10537-47-0 MFCD00209853
化学结构图
SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N
化学属性
| Mol. Formula | C18H22N2O |
|---|---|
| Mol. Weight | 282.39 |
| Melting Point | 139.0 to 147.0 deg-C |
别名和识别编码
| Chemical Name | Tyrphostin A9 |
|---|---|
| Synonym | (3,5-Di-t-butyl-4-hydroxybenzylidene)malononitrile 2-((3,5-Bis(1,1-dimethyl)-4-hydroxyphenyl)methylene)propanedinitrile ENT 27910 GCP 5126 Gulf S-15126 Malonoben Malonoben [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile Propanedinitrile, Tyrphostin A9 [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile |
| CAS Number | 10537-47-0 |
| PubChem Substance ID | 24278069 |
| MDL Number | MFCD00209853 |
| Wiswesser Line Notation | NCYCN&U1R DQ CX1&1&1 EX1&1&1 |
| Beilstein Registry Number | 2700764 |
| Reaxys-RN | 2700764 |
| Chemical Name Translation | 2-(3,5-二叔丁基-4-羟基苯亚甲基)丙二腈 |
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分类
- Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Chromatography, Environmental Standards, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibitors and Activators, Insecticides, Ion Channels, Kinase/Phosphatase Biology, Others, P to Q, Pesticides, Pesticides & Metabolites, Platelet Derived Growth Factor Receptor (PDGFR), Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase B
相关文献及参考
- Levitzki, A., Gilon, C, Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol. Sci. 12 , 171-174, (1991) 摘要
- Bilder, et al., Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am. J. Physiol. 260 , C721-C730, (1991) 摘要
- Denys, A., et al., Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activatory-inhibitory action of docosahexaenoic acid. FEBS Lett. 564 , 177-182, (2004) 摘要
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H301+H311
- H301+H311+H331
- H311 Toxic in contact with skin 皮肤接触中毒
- H331 Toxic if inhaled 吸入中毒
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310+P330
- P302+P352+P312+P361+P364
- P304+P340+P311
- P305+P351+P338+P337+P313
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 226 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 74-1,-,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 87 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,21,1978
