DPCPX DPCPX
CAS 102146-07-6 MFCD00055117
化学结构图
SMILES: CCCN1C(=O)C2NC(=NC=2N(CCC)C1=O)C1CCCC1
化学属性
| Mol. Formula | C16H24N4O2 |
|---|---|
| Mol. Weight | 304 |
别名和识别编码
| Chemical Name | DPCPX |
|---|---|
| CAS Number | 102146-07-6 |
| Synonym | 1,3-Dipropyl-8-cyclopentylxanthine DPCPX PD 116,948 8-Cyclopentyl-1,3-dipropylxanthine 8-Cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione DPCPX, PD 116,948 |
| MDL Number | MFCD00055117 |
| PubChem Substance ID | 24277697 |
| Chemical Name Translation | DPCPX |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists,
- Heterocycles
- Inhibitors
- {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, CI-CZ, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
- Neurochemicals
- {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, CI-CY, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives
产品应用
- DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an a
相关文献及参考
- [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63.
- [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P–535P.
- Gessi, S., et al.: Mol. Pharmacol., 67, 2137 (2005),
- Gracia, E., et al.: J. Neurochem., 107, 161 (2008),
- Minor, T.R., et al.: Behav. Neurosci., 122, 1236 (2008),
- [1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61.
- [1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61.
- [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63.
- [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
