CAS 101-77-9 MFCD00007914-4,4'-Methylenedianiline 4,4-二氨基二苯甲烷 TAO{mole}

4,4'-Methylenedianiline 4,4-二氨基二苯甲烷

CAS 101-77-9 MFCD00007914

化学结构图

SMILES: NC1CCC(CC2CCC(N)CC2)CC1

化学属性

Mol. Formula	C13H14N2
Mol. Weight	198.26
Melting Point	91.0 to 94.0 deg-C
Flash Point	221°(429°F)
TSCA	Yes
Boiling Point	257°C/18mmHg(lit.)
Density	1.15
Solubility	难溶于水，易溶于乙醇、乙醚、苯。
Stability	对空气敏感

别名和识别编码

Chemical Name	4,4'-Methylenedianiline
MDL Number	MFCD00007914
CAS Number	101-77-9
Synonym	4,4'-Methylenedianiline {LY} 4,4'-Methylenedianiline 4,4-METHYLENEDIANILINE 4,4’-二氨基二苯基甲烷 4,4’-二氨基代二苯基甲烷 4,4’-甲撑二苯胺 4,4′-Methylenedianiline Ancamine TL Benzenam DADPM Di-(4-aminophenyl)methane Diaminodiphenylmethane Epicure DDM HT 972 Jeffamine AP-20 P,P'-DIAMINODIPHENYLMETHANE bis(p-aminophenyl)methane p,p'-Diaminodifenylmethan p,p'-Diaminodiphenylmethane p,p'-Methylenedianiline {} {LY} 4,4'-Methylenedianiline {} {} {LY} 4,4'-Methylenedianiline {} {} {} {LY} 4,4'-Methylenedianiline {} {} {} {} {} {} {} {} {LY} 4,4'-Methylenedianiline {} {} {} {} {} {LY} 4,4'-Methylenedianiline {} {} {} {} {} {} {LY} 4,4'-Methylenedianiline {} {} {} {} {} {} {} {LY} 4,4'-Methylenedianiline {} {} {} {} {} {} {} {} {LY} 4,4'-Methylenedianil
EC Number	202-974-4
Beilstein Registry Number	13,238
PubChem Substance ID	87572310
Merck Number	2980
Reaxys-RN	474706
Chemical Name Translation	4,4-二氨基二苯甲烷
Wiswesser Line Notation	ZR D1R DZ
LabNetwork Molecule ID	LN00225979
InChI	InChI=1S/C13H14N2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9,14-15H2
Canonical SMILES	NC1=CC=C(CC2=CC=C(N)C=C2)C=C1

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产品应用

制造染料，测定钨及硫酸盐，橡胶的抗氧剂和防老剂。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H350 May cause cancer 可能致癌
H370 Causes damage to organs 导致器官损伤
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSBY5425000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P302+P350
P302+P352+P312+P361+P364
P305+P351+P338
P305+P351+P338+P337+P313
P307+P311
P308+P311
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P337+P313
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Packing GroupIII

UN Number 2651 UN 2651 6.1/PG 3

Risk Statements

R45 May cause cancer 可能致癌
R48/20/21/22
R51/53
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Hazard Codes T,N

Hazard Class6.1

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 219,1162,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1410 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   57,247,1970

TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 1159

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 193 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 20,393,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 20,393,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 11,185,1978

TYPE OF TEST            : LD50 - L

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,123,1979

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 9 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 108,225,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,683,1988

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 370 umol/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 2,1317,1981

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

Alfa Aesar:4,4'-二氨基二苯甲烷,97% 4,4'-Diaminodiphenylmethane, 97%(101-77-9)
易溶于醇、醚和苯，难溶于冷水，遇光变黑现象，久贮易结块。
用途三:用作分析试剂，也用于有机合成
职业标准:TWA 0.8 毫克/立方米; STEL 4.0 毫克/立方米
MOL 文件:101-77-9.mol
Acros Organics:4,4'-亚甲基二苯胺 4,4'-Methylenedianiline, 97%(101-77-9)
用途一:主要用于轮胎、胎侧、帘布层、内胎、输送管、胶管、三角带等橡胶制品中
刺激数据:眼睛-兔子 100 毫克/24小时中度
用途四:制造染料，测定钨及硫酸盐，橡胶的抗氧剂和防老剂。
类别:有毒物品
外观性质:淡黄色结晶，遇光变成黑色。
Sigma Aldrich:101-77-9(sigmaaldrich)
可燃性危险特性:明火可燃; 受热放出有毒氧化氮气体
下游产品:新型光敏聚酰亚胺/SIO2杂化材料 --> 盐酸氟桂利嗪
图谱信息:4,4'-二氨基二苯甲烷(101-77-9)红外图谱(IR2) 4,4'-二氨基二苯甲烷(101-77-9)红外图谱(IR1) 4,4'-二氨基二苯甲烷(101-77-9)核磁图( 13 CNMR) 4,4'-二氨基二苯甲烷(101-77-9)质谱(MS)
上游原料:氢氧化钠 --> 盐酸 --> 甲醛 --> 氨基苯 --> 碳酸钙 --> 苯乙烯 --> 苯磺酸
4,4'-二氨基二苯甲烷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 81014326 4，4-二氨基二苯甲烷 100g 11.9元 2011/04/16 M0220 4,4'-二氨基二苯基甲烷 4,4'-Diaminodiphenylmethane 25G 92元 2011/04/16 M0220 4,4'-二氨基二苯基甲烷 4,4'-Diaminodiphenylmethane 500G 386元
储运特性:库房通风低温干燥; 与食品原料分开储运
毒性分级:中毒
急性毒性:口服-大鼠 LD50: 662 毫克/公斤; 口服-小鼠 LD50: 745 毫克/公斤
用途二:用于生产绝缘材料、染料、二异氰酸酯、聚氨酯橡胶、H级粘合剂、环氧树脂固化剂等
MSDS 信息:4,4'-亚甲基双苯胺(101-77-9).msds
灭火剂:水、二氧化碳、砂土、泡沫