CAS 101-21-3 MFCD00037108-Isopropyl (3-Chlorophenyl)Carbamate (3-氯苯基)氨基甲酸异丙酯 TAO{mole}

Isopropyl (3-Chlorophenyl)Carbamate (3-氯苯基)氨基甲酸异丙酯

CAS 101-21-3 MFCD00037108

化学结构图

SMILES: CC(C)OC(=O)Nc1cccc(Cl)c1

化学属性

Mol. Formula	C10H12ClNO2
Mol. Weight	213.66
Melting Point	36-38°C
Boiling Point	248°C at 760 mmHg
Density	1.18
Solubility	0.009 G/100 ML VERY POOR
Flash Point	153.3°C
Appearance	crystalline

别名和识别编码

Chemical Name	Isopropyl (3-Chlorophenyl)Carbamate
MDL Number	MFCD00037108
CAS Number	101-21-3
Synonym	Chlorpropham {LY} Chlorpropham {} {LY} Chlorpropham {} {} {LY} Chlorpropham {} {} {} {LY} Chlorpropham {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	2728
Beilstein Registry Number	2211397
EC Number	202-925-7
Chemical Name Translation	(3-氯苯基)氨基甲酸异丙酯
Merck Number	13,2206
Wiswesser Line Notation	GR CMVOY1&1
InChI	InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)
Canonical SMILES	O=C(NC1=CC=CC(Cl)=C1)OC(C)C

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品牌质保精细包装现货库存一流品牌服务

产品应用

有丝分裂毒药;抑制植物代谢。
农业上用作选择性芽前除草剂，防除胡萝卜、韭葱、洋葱等作物中的杂草。

安全信息

GHS Symbol

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P301+P312+P330
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H302 Harmful if swallowed 吞食有害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H332 Harmful if inhaled 吸入有害
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H312 Harmful in contact with skin 皮肤接触有害

WGK Germany2

RTECSFD8050000

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves

Signal word Danger Warning

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Hazard Codes Xn,N,F F,Xn Xn,N

Risk Statements

R36 Irritating to eyes 刺激眼睛
R11 Highly flammable 非常易燃
R22 Harmful if swallowed 吞咽有害
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R51/53

Storage condition 2-8°C {LY} 2-8°C APPROX 4°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

UN Number UN 3077 9/PG 3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   12,355,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C73,1991

{h

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAREAQ Pharmacological Reviews.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1949-  Volume(issue)/page/year: 14,225,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 175,496,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUT

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,414,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,468,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,638,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 31500 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volum

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   ABILAE Archives de Biologie (1880-1985).  (Liege, Belgium)  V.1-96(1),
   1880-1985.  Volume(issue)/page/year: 92,367,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 4 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,528,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 gm/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   11,697,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 9 gm/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

其他信息

1000μg/ml,溶于吹扫-捕集甲醇溶液中
急性毒性:口服- 大鼠 LD50: 1200 毫克/ 公斤
毒性分级:中毒
Sigma Aldrich:101-21-3(sigmaaldrich)
急救治疗:用阿托品0.5－2mg口服或肌肉注射，重者加用肾上素。禁用解磷定，氯磷定，双复磷，吗啡
用途一:用于抑制马铃薯贮藏期发芽
灭火剂:干粉、泡沫、砂土
中毒症状:对眼和皮肤有刺激作用，浓度大时轻度抑制胆碱酯酶。
MSDS 信息:间氯苯氨基甲酸异丙酯(101-21-3).msds
color:light tan
毒性:大鼠急性经口LD 50 为5000～7500mg/kg（原药为4200mg/kg)，兔急性经皮LD 50 >2000mg/kg。对眼睛稍有刺激性，对皮肤无刺激性。动物试验未见致畸、致突变作用，大鼠慢性毒性试验和致癌作用试验无作用剂量为每天30mg/kg。
用途三:选择性芽前除草剂，防除胡萝卜、韭葱、洋葱等作物中的杂草
溶解度(25°C):水中89mg/L，煤油中100g/L，可与醇类、芳香烃及大多数有机溶剂混溶。
上游原料:氯甲酸异丙酯 --> 间氯苯异氰酸酯
可燃性危险特性:燃烧产生有毒氮氧化物和氯化物气体
储运特性:库房通风低温干燥; 与食品原料分开储运
用途二:既是植物生长调节剂又是除草剂。具有抑制β-淀粉酶活性，抑制植物RNA、蛋白质的合成，干扰氧化磷酸化和光合作用，破坏细胞分裂，因而能显著地抑制马铃薯贮存时的发芽力。也可用于果树的疏花、疏果。同时氯苯胺灵是一种高度选择性苗前或苗后早期除草剂，药剂被禾本科杂草芽鞘吸收，以植物的根部吸收为主，也可被叶片吸收，在体内向上、向下双向传导，能有效防除小麦、玉米、苜蓿、向日葵、马铃薯、甜菜、大豆、水稻、菜豆、胡萝卜、菠菜、莴苣、洋葱、辣椒等作物地中一年生禾本科杂草和部分阔叶草。用于马铃薯抑芽，在收获后待损伤自然愈合（约14d以上）和出芽前使用，将药剂混细干土均匀撒于马铃薯上，使用剂量为每吨马铃薯用0.7%粉剂1.4～2.1kg(有效成分9.8～14.7g)；或用2.5%粉剂400～600g (有效成分10～15g)。用于防除的杂草主要有生禾苗、稗草、野燕麦、早熟禾、荠菜、苋、燕麦草、多花黑麦草、繁缕、粟米草、萹蓄、马齿苋、田野菟丝子等。在作物播后苗前进行土壤处理，用0.7%粉剂157～425kg/hm 2 单用或混用，可防除敏感杂草。根据土壤有机质、温度不同，适当增大用量可扩大杀草谱。
类别:农药
MOL 文件:101-21-3.mol
方法一:氯苯胺灵可由3-氯苯基异氰酸酯与异丙醇作用制得。或由3-氯苯胺与氯甲酸异丙酯作用制得。
注意事项:吞入时,饮水并导吐. 吸入时,移至新鲜空气处并供氧. 溅入眼中,用大量水冲洗. 如皮肤接触,则用肥皂清洗并用清水冲洗.
职业标准:STEL 2 毫克/ 立方米
Decomposition:247 °C
稳定性:低于100℃下稳定,在酸、碱介质中缓慢水解
外观:淡棕色结晶，具有轻微的特殊的气味
可与醇类、芳香烃及大多数有机溶剂混溶，在酸、碱介质中缓慢水解。